Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Jun 12, 2023 - Meiling joins the lab
We are thrilled to welcome Meiling to the Mattis lab as our second postdoc! Meiling completed her PhD in the Department of Molecular, Cellular, and Developmental Biology, along with a dual master's degree in the Department of Computational Medicine and Bioinformatics, both at the University of Michigan. Working in Sam Kwon's lab, she uncovered neuronal mechanisms of impaired perceptual learning associated with neurodevelopmental disorders using a mouse model of Synaptic Ras-GTPase-activating protein (SynGAP), behavioral testing, and in vivo two-photon calcium imaging.

Jun 05, 2023 - Krystal is selected for the PSTP T32!
We are so excited to share the news that Krystal has been selected to to be appointed as a trainee on the highly competitive Pharmacological Sciences Training Program (PSTP) T32 training grant. This training program is a collaboration between the Medical School and the College of Pharmacy, designed to provide translational education, research training, and career development for trainees, to equip them as leaders in the field of experimental therapeutics. Congratulations, Krystal!!!

Jun 05, 2023 - Mattis lab receives a Research Scouts Award!
We are thrilled to be the recipients of a Scouts Award from the University of Michigan. The Research Scouts program is an investment in the "Bold Science" objective of Michigan Medicine's research strategic plan, with the goal of catalyzing new and exciting lines of investigation. Scouts Awards are intended to fund early stage ideas that challenge common dogma and have the potential to be paradigm shifting. Thank you to the Research Scout who selected our lab!

Jun 02, 2023 - Chandni is selected for the NETP T32!
Chandni has been awarded the highly competitive Neural Engineering Training Program (NETP) T32. The NETP enhances the graduate school experience of trainees with a wide variety of activities (seminars, journal clubs, an annual symposium, social events, and workshops) focused on neural engineering. Congratulations, Chandni!!!

May 15, 2023 - Chandni presents at the NETP Symptosium
Chandni presented her project at the annual Neural Engineering Training Program Symposium. This was our lab's first presentation of new data (collected within the Mattis lab), which is a major milestone!

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