Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Apr 14, 2023 - First fiber photometry experiment is underway!
So thrilled to be collecting fiber photometry and ECoG data during seizures! Great job Chandni, and thank you so much to Burgess lab collaborating with us on this!

Apr 03, 2023 - Chandni is selected as a student rep for the NGP DEI committee
Congratulations, Chandni!

Mar 24, 2023 - Chandni officially joins the lab
We are very excited to welcome Chandni Rana as a graduate student in the Mattis lab! Chandni graduated from the University of Florida with a B.S. in Biomedical Engineering and gained additional experience as a lab technician at NYU. She is a student in the Neuroscience Graduate Program (NGP) at the University of Michigan.

Mar 01, 2023 - Krystal officially joins the lab
We are thrilled to welcome Krystal M. Santiago-Colón as the lab's first official graduate student! Krystal graduated from the University of Puerto Rico, Cayey Campus with a B.S. in Biology in 2022. She is a student in the Program in Biomedical Sciences (PIBS) and the Department of Pharmacology. Krystal will be jointly mentored by Dr. Lori Isom, Chair of the Department of Pharmacology.

Feb 28, 2023 - Setting up an automated fluorescent microscope + stereology system!
Today our new automated Nikon fluorescent microscope was installed! We'll be using this alongside a MBF Biosciences software for stereology. So excited to start taking pictures on this microscope!

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