Dec 08, 2025 - AES 2025
Congratulations to Krystal and Meiling for their posters at this year's American Epilepsy Society conference. (Krystal had the opportunity to present hers 3 times!) Pictured is Krystal presenting her SUDEP project to one of the giants in the field.
Nov 17, 2025 - Society for Neuroscience 2025
Our lab presented 4 posters at SfN this year! All projects are approaching submission for publication and it was a great opportunity to get feedback. Congratulations to Ruitao, Chandni, Krystal, and Meiling for their great work!
Our lab presented 4 posters at SfN this year! All projects are approaching submission for publication and it was a great opportunity to get feedback. Congratulations to Ruitao, Chandni, Krystal, and Meiling for their great work!
Nov 13, 2025 - Distinct Circuit Mechanisms in Epilepsies
Joanna gave a talk at "Distinct Circuit Mechanisms in Epilepsies" - a.k.a. "Huguenardapalooza" - an SfN pre-meeting organized in honor of Dr. John Huguenard, one of Joanna's PhD mentors at Stanford. Thank you to the organizers for the invitation, and congratulations, Dr. Huguenard, on your many accomplishments as a scientist and as a mentor!
Joanna gave a talk at "Distinct Circuit Mechanisms in Epilepsies" - a.k.a. "Huguenardapalooza" - an SfN pre-meeting organized in honor of Dr. John Huguenard, one of Joanna's PhD mentors at Stanford. Thank you to the organizers for the invitation, and congratulations, Dr. Huguenard, on your many accomplishments as a scientist and as a mentor!
Oct 24, 2025 - Halloween “Horror Night”
The lab celebrated an early Halloween with dinner out followed by a haunted house expedition. Spooky fun was had by all!
The lab celebrated an early Halloween with dinner out followed by a haunted house expedition. Spooky fun was had by all!
Oct 10, 2025 - Joanna is a “camp doc” for the Epilepsy Foundation of Michigan’s Family Camp
Joanna had the privilege of serving as a "camp doc" for the Epilepsy Foundation of Michigan's annual "Family Camp," attended by children with epilepsy and their families. The camp weekend was held at North Star Reach (https://www.northstarreach.org/), a medically supported camp that enables children with medical conditions (and their families) to enjoy a joyful camp experience.
Joanna had the privilege of serving as a "camp doc" for the Epilepsy Foundation of Michigan's annual "Family Camp," attended by children with epilepsy and their families. The camp weekend was held at North Star Reach (https://www.northstarreach.org/), a medically supported camp that enables children with medical conditions (and their families) to enjoy a joyful camp experience.
Oct 06, 2025 - Ruitao receives a Biology Travel Award
Congratulations to Ruitao for receiving a Biology Travel Award! This will support his attendance at the 2025 Society for Neuroscience conference, at which he will be the presenting author on a poster about hyperthermia-evoked seizures in a mouse model of Focal Cortical Dysplasia.
Congratulations to Ruitao for receiving a Biology Travel Award! This will support his attendance at the 2025 Society for Neuroscience conference, at which he will be the presenting author on a poster about hyperthermia-evoked seizures in a mouse model of Focal Cortical Dysplasia.
Sep 24, 2025 - Joanna gives Grand Rounds at the University of Pennsylvania
Joanna was privileged with an invitation to present Grand Rounds to the Department of Neurology at the University of Pennsylvania, where she completed her neurology residency, epilepsy fellowship, and R25 and early K08 research training. It was fantastic to get the chance to share the lab's work with such a great community of clinicians and scientists. Thank you for the invitation, Penn!
Joanna was privileged with an invitation to present Grand Rounds to the Department of Neurology at the University of Pennsylvania, where she completed her neurology residency, epilepsy fellowship, and R25 and early K08 research training. It was fantastic to get the chance to share the lab's work with such a great community of clinicians and scientists. Thank you for the invitation, Penn!
Sep 23, 2025 - Welcoming new undergrads to the Mattis lab!
We are glad to welcome several new undergraduate students to the Mattis lab. Silvia Abbasi, junior pre-medical student, will join a new direction in the lab involving analysis of clinical epilepsy data. Arnav Akhaury, a freshman and aspiring future neurosurgeon, will be working with Meiling to study noradrenergic circuits in epilepsy. Yousif Ogaily, a sophomore BCN major, will be working with Joe as part of a team investigating the medial septum's role in seizures. Farah Abdelhak, a freshman MCDB major on the pre-med track, will be working with Krystal to investigate the impact of repeated seizures on brainstem respiratory circuitry.
We are glad to welcome several new undergraduate students to the Mattis lab. Silvia Abbasi, junior pre-medical student, will join a new direction in the lab involving analysis of clinical epilepsy data. Arnav Akhaury, a freshman and aspiring future neurosurgeon, will be working with Meiling to study noradrenergic circuits in epilepsy. Yousif Ogaily, a sophomore BCN major, will be working with Joe as part of a team investigating the medial septum's role in seizures. Farah Abdelhak, a freshman MCDB major on the pre-med track, will be working with Krystal to investigate the impact of repeated seizures on brainstem respiratory circuitry.
Sep 18, 2025 - Joanna joins the Epilepsy Foundation of Michigan’s Professional Advisory Committee
Joanna was honored to be invited to join the Epilepsy Foundation of Michigan's Professional Advisory Committee (PAC). The PAC provides policy guidance and technical assistance to the Team and Board of the Epilepsy Foundation of Michigan, a statewide nonprofit organization that provides information, resources, and support to individuals living with epilepsy.
Joanna was honored to be invited to join the Epilepsy Foundation of Michigan's Professional Advisory Committee (PAC). The PAC provides policy guidance and technical assistance to the Team and Board of the Epilepsy Foundation of Michigan, a statewide nonprofit organization that provides information, resources, and support to individuals living with epilepsy.
Sep 17, 2025 - Joanna joins the ANA Junior and Early Career Membership (JECM) Subcommittee
Joanna was approved to serve on the American Neurological Association's Junior and Early Career Membership (JECM) Subcommittee, tasked with "enhancing engagement and support recruitment, retention, and representation of junior and early career members". This will be a great opportunity to become more involved with the ANA, the professional society devoted to academic researchers and physician-scientists in neurology.
Joanna was approved to serve on the American Neurological Association's Junior and Early Career Membership (JECM) Subcommittee, tasked with "enhancing engagement and support recruitment, retention, and representation of junior and early career members". This will be a great opportunity to become more involved with the ANA, the professional society devoted to academic researchers and physician-scientists in neurology.
Sep 16, 2025 - Joanna presents at the American Neurological Association (ANA) meeting
Joanna attended the ANA-NINDS Career Development Symposium (as a K-awardee) and presented the lab's work both at the symposium and at the associated ANA meeting (which was incidentally the 150th annual meeting of the ANA).
Joanna attended the ANA-NINDS Career Development Symposium (as a K-awardee) and presented the lab's work both at the symposium and at the associated ANA meeting (which was incidentally the 150th annual meeting of the ANA).
Aug 15, 2025 - Krystal selected for an SfN Trainee Professional Development Award
Congratulations to Krystal for being selected for a 2025 Trainee Professional Development Award (TPDA) through the Society for Neuroscience! This award will facilitate her attendance at the 2025 SfN conference and will provide access to a variety of professional development and training resources. Way to go, Krystal!
Congratulations to Krystal for being selected for a 2025 Trainee Professional Development Award (TPDA) through the Society for Neuroscience! This award will facilitate her attendance at the 2025 SfN conference and will provide access to a variety of professional development and training resources. Way to go, Krystal!
Aug 08, 2025 - The Mattis lab joins Bing Ye’s NIH R01 grant
We are thrilled to join Dr. Bing Ye's laboratory in dissecting hippocampal circuit pathology in Down syndrome mouse models. This collaboration, "Molecular regulators of GABAergic systems that underlie comorbidities in Down syndrome," will build from Joanna's postdoctoral work investigating corticohippocampal circuits in a Dravet Syndrome mouse model, and represents an exciting new scientific direction for the Mattis lab. Thank you to the National Institutes of Health for supporting this work.
We are thrilled to join Dr. Bing Ye's laboratory in dissecting hippocampal circuit pathology in Down syndrome mouse models. This collaboration, "Molecular regulators of GABAergic systems that underlie comorbidities in Down syndrome," will build from Joanna's postdoctoral work investigating corticohippocampal circuits in a Dravet Syndrome mouse model, and represents an exciting new scientific direction for the Mattis lab. Thank you to the National Institutes of Health for supporting this work.
Aug 07, 2025 - Chandni receives an NRSA (F31) from NINDS!
Congratulations to Chandni for being awarded a Ruth L. Kirschstein National Research Service Award (NRSA) to support the remainder of her dissertation research in the lab. This project, "The nigrotegmental circuit in an Scn1a+/- mouse model of Dravet Syndrome" focuses on crucial "choke point" regions that may be capable of exerting modulatory control over seizures. Thank you to the National Institutes of Health for supporting this work, and Chandni's career!
Congratulations to Chandni for being awarded a Ruth L. Kirschstein National Research Service Award (NRSA) to support the remainder of her dissertation research in the lab. This project, "The nigrotegmental circuit in an Scn1a+/- mouse model of Dravet Syndrome" focuses on crucial "choke point" regions that may be capable of exerting modulatory control over seizures. Thank you to the National Institutes of Health for supporting this work, and Chandni's career!
Aug 06, 2025 - Sreyashi awarded U@MNI scholarship
Congratulations to Sreyashi for being awarded a U@MNI research position for 2025-2026! This is a funded position through the Michigan Neuroscience Institute. In addition to supporting Sreyashi's work in the lab, U@MNI also offers a series of social and professional development meetings - organized by Neuroscience Graduate Program PhD students - culminating in a poster presentation to showcase undergraduate research. Congrats, Sreyashi!
Congratulations to Sreyashi for being awarded a U@MNI research position for 2025-2026! This is a funded position through the Michigan Neuroscience Institute. In addition to supporting Sreyashi's work in the lab, U@MNI also offers a series of social and professional development meetings - organized by Neuroscience Graduate Program PhD students - culminating in a poster presentation to showcase undergraduate research. Congrats, Sreyashi!
Aug 06, 2025 - The Mattis lab receives its first NIH R01 grant!
We are thrilled to have received the Notice of Award for the lab's first NIH R01 grant. This project, entitled "Seizure-Induced Remodeling of Cholinergic Networks in Dravet Syndrome," will explore mechanistic links between seizures and epilepsy comorbidities, with a focus on the cholinergic brainstem. We are so grateful to National Institute of Neurological Disorders and Stroke (NINDS) for supporting our lab's work.
We are thrilled to have received the Notice of Award for the lab's first NIH R01 grant. This project, entitled "Seizure-Induced Remodeling of Cholinergic Networks in Dravet Syndrome," will explore mechanistic links between seizures and epilepsy comorbidities, with a focus on the cholinergic brainstem. We are so grateful to National Institute of Neurological Disorders and Stroke (NINDS) for supporting our lab's work.
Jul 31, 2025 - Alex H. presents his summer work
Congratulations to Alex for a terrific poster at the 2025 Magnificent Michigan poster session. Alex had an extremely productive summer, which was supported by two UofM undergraduate research scholarships. Well done, Alex!
Jul 07, 2025 - Limei’s paper is published in Epilepsia!
Congratulations to Limei and team for their Epilepsia publication, Medial septum parvalbumin-expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome. We employed whole cell patch clamping in acute brain slices to identify significant hypoexcitability of inhibitory neurons within the medial septum in Scn1a+/- mice. This work identifies the medial septum as a pathologic region and suggests its importance for cognitive impairment in Dravet syndrome. We are excited to extend this work in vivo -- stay tuned!
Congratulations to Limei and team for their Epilepsia publication, Medial septum parvalbumin-expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome. We employed whole cell patch clamping in acute brain slices to identify significant hypoexcitability of inhibitory neurons within the medial septum in Scn1a+/- mice. This work identifies the medial septum as a pathologic region and suggests its importance for cognitive impairment in Dravet syndrome. We are excited to extend this work in vivo -- stay tuned!
Jun 14, 2025 - 2025 Metro Detroit Stroll for Epilepsy
Members of our lab and other UofM faculty, staff, and students joined the 2025 Metro Detroit Stroll for Epilepsy, organized by the Michigan Epilepsy Foundation. It was an inspirational event, with many epilepsy patients and their families in attendance, and a beautiful day to enjoy the Detroit Zoo!
Members of our lab and other UofM faculty, staff, and students joined the 2025 Metro Detroit Stroll for Epilepsy, organized by the Michigan Epilepsy Foundation. It was an inspirational event, with many epilepsy patients and their families in attendance, and a beautiful day to enjoy the Detroit Zoo!
Jun 06, 2025 - Krystal gives a talk at the 2025 Pharmacology in Color Symposium
Congratulations to Krystal on her excellent invited talk at this year's Pharmacology in Color Symposium. Krystal shared her exciting preliminary data regarding mechanisms of Sudden Unexpected Death in Epilepsy (SUDEP), the most dreaded complication of epilepsy. Well done, Krystal!
Congratulations to Krystal on her excellent invited talk at this year's Pharmacology in Color Symposium. Krystal shared her exciting preliminary data regarding mechanisms of Sudden Unexpected Death in Epilepsy (SUDEP), the most dreaded complication of epilepsy. Well done, Krystal!
May 16, 2025 - Nagham’s poster is selected for a prize at the U-M Neuroscience conference
Nagham's poster was selected (based upon votes by conference attendees) for a prize at the University of Michigan Neuroscience conference. This was notably a general prize, not limited to undergraduate students. Congratulations, Nagham!
Nagham's poster was selected (based upon votes by conference attendees) for a prize at the University of Michigan Neuroscience conference. This was notably a general prize, not limited to undergraduate students. Congratulations, Nagham!
May 04, 2025 - Congratulations to graduates from our lab!
Congrats to Joe (MCDB) for completing his master's, and to Izzy and Rida (Neuroscience) and Nagham (Psychology) for completing their undergraduate degrees. Major milestones all around!
Congrats to Joe (MCDB) for completing his master's, and to Izzy and Rida (Neuroscience) and Nagham (Psychology) for completing their undergraduate degrees. Major milestones all around!
Apr 28, 2025 - Congratulations to our seniors!
A lovely evening celebrating our lab's seniors - Juan, Nagham, Izzy, and Rida - and their mentors. Thank you, all, for your contributions to the lab. And congratulations!
A lovely evening celebrating our lab's seniors - Juan, Nagham, Izzy, and Rida - and their mentors. Thank you, all, for your contributions to the lab. And congratulations!
Apr 28, 2025 - Alex & Ruitao awarded summer research fellowships
Alex Hollier and Ruitao Shen were both awarded undergraduate Neuroscience Summer Research Fellowships through the UM Program in Biology. This will support their full time summer research in the lab. Congrats, Alex & Ruitao!
Alex Hollier and Ruitao Shen were both awarded undergraduate Neuroscience Summer Research Fellowships through the UM Program in Biology. This will support their full time summer research in the lab. Congrats, Alex & Ruitao!
Apr 07, 2025 - Alex awarded a Magnificent Michigan Summer Undergraduate research fellowship
Alex Hollier was awarded a Magnificent Michigan Summer Undergraduate research fellowship to support his full time work in the lab this summer. Congratulations, Alex!
Alex Hollier was awarded a Magnificent Michigan Summer Undergraduate research fellowship to support his full time work in the lab this summer. Congratulations, Alex!
Apr 07, 2025 - Nagham selected as Psychology department nominee for LSA honors
Nagham was selected as the Psychology department nominee for both the Elizabeth Hume O'Donnell Honors Graduation Prize and the Marshall Nirenberg Life Sciences Award (Goldstein Prize) LSA Honors awards. This nomination was based on the quality of her senior honor's thesis and her overall research performance throughout her time as an undergraduate student in the lab. Congratulations, Nagham, on this well-deserved honor!
Nagham was selected as the Psychology department nominee for both the Elizabeth Hume O'Donnell Honors Graduation Prize and the Marshall Nirenberg Life Sciences Award (Goldstein Prize) LSA Honors awards. This nomination was based on the quality of her senior honor's thesis and her overall research performance throughout her time as an undergraduate student in the lab. Congratulations, Nagham, on this well-deserved honor!
Apr 01, 2025 - Welcoming a “mini team” of CS undergrads to the Mattis lab!
We are very excited to welcome a "mini team" of UMich CS students to the lab to contribute to our data analysis efforts! Sreyashi Mondal and Alexander Sajdak are sophomores studying CS. Saif Siddiqui is a junior studying CS on the pre-medical track. We think there's a lot to gain by bringing computer science students into a neuroscience lab, and we are looking forward to working together!
We are very excited to welcome a "mini team" of UMich CS students to the lab to contribute to our data analysis efforts! Sreyashi Mondal and Alexander Sajdak are sophomores studying CS. Saif Siddiqui is a junior studying CS on the pre-medical track. We think there's a lot to gain by bringing computer science students into a neuroscience lab, and we are looking forward to working together!
Mar 03, 2025 - Our work is highlighted as part of the UM Medical School’s “Great Minds, Greater Discoveries” strategic research plan
We were privileged to have our Research Scouts award project publicized by the University of Michigan Medical School. Thank you to the Research Communication team for helping us to share our work!
We were privileged to have our Research Scouts award project publicized by the University of Michigan Medical School. Thank you to the Research Communication team for helping us to share our work!
Feb 17, 2025 - Joanna gives a talk at the annual Biophysical Society Conference
Joanna was an invited speaker at the "Optogenetics: From Signaling to Cell Behavior" symposium at the Biophysical Society 69th Annual Meeting in Los Angeles. Thank you to the organizers for the invitation!
Joanna was an invited speaker at the "Optogenetics: From Signaling to Cell Behavior" symposium at the Biophysical Society 69th Annual Meeting in Los Angeles. Thank you to the organizers for the invitation!
Feb 17, 2025 - Meiling receives the Mary & Peter Jessel Gift
Meiling was awarded a gift provided by Drs. Mary (Heng) Jessel and Peter Jessel in honor of the memory of Dr. Thomas Heng, Dr. Mary Jessel's late father. This award is intended to support a Neuroscience Graduate Student or Post-Doctoral Fellow in the laboratory of a Department of Neurology investigator. We are very grateful to the Jessels for this generous gift, which will support Meiling's postdoctoral work this year. Congratulations, Meiling!
Meiling was awarded a gift provided by Drs. Mary (Heng) Jessel and Peter Jessel in honor of the memory of Dr. Thomas Heng, Dr. Mary Jessel's late father. This award is intended to support a Neuroscience Graduate Student or Post-Doctoral Fellow in the laboratory of a Department of Neurology investigator. We are very grateful to the Jessels for this generous gift, which will support Meiling's postdoctoral work this year. Congratulations, Meiling!
Feb 07, 2025 - New undergraduate student joins the lab
We are excited to welcome Ruitao to the lab! He is a junior at UofM and plans to pursue a PhD upon graduation. Ruitao will be working with Chandni and Xiaogang to study seizure mechanisms in a mouse model of Focal Cortical Dysplasia.
We are excited to welcome Ruitao to the lab! He is a junior at UofM and plans to pursue a PhD upon graduation. Ruitao will be working with Chandni and Xiaogang to study seizure mechanisms in a mouse model of Focal Cortical Dysplasia.
Jan 13, 2025 - Visiting Scholar joins the lab
We are honored to welcome our first visiting scholar, Xiaogang Zhang, to the Mattis lab! Dr. Zhang is a physician scientist from China, where he holds a title of Associate Chief Physician and Associate Chief Physician Deputy Director in the Department of Neurology at Chongqing General Hospital, Chongqing University. He brings clinical and research expertise in epilepsy to the lab, and we are thrilled to have him join the team for a year. Welcome, Xiaogang!
We are honored to welcome our first visiting scholar, Xiaogang Zhang, to the Mattis lab! Dr. Zhang is a physician scientist from China, where he holds a title of Associate Chief Physician and Associate Chief Physician Deputy Director in the Department of Neurology at Chongqing General Hospital, Chongqing University. He brings clinical and research expertise in epilepsy to the lab, and we are thrilled to have him join the team for a year. Welcome, Xiaogang!
Jan 08, 2025 - New undergraduate students join the lab
We are happy to welcome two new undergraduate students to the lab: Mia (freshman) and Alex (sophomore). They both connected with the lab in the fall and are officially getting started this winter semester. Welcome!
We are happy to welcome two new undergraduate students to the lab: Mia (freshman) and Alex (sophomore). They both connected with the lab in the fall and are officially getting started this winter semester. Welcome!
Jan 02, 2025 - Publication with the Burgess lab in J Neurosci
We are excited to see our first collaboration with Christian Burgess's lab published in the Journal of Neuroscience: Melanin concentrating hormone projections to the nucleus accumbens enhance the reward value of food consumption and do not induce feeding or REM sleep. Congratulations to first author Katherine Furman (graduate student in the Burgess lab) and to Limei (in the Mattis lab) for her contributions to this publication. This should be the first of many collaborations between our labs!
We are excited to see our first collaboration with Christian Burgess's lab published in the Journal of Neuroscience: Melanin concentrating hormone projections to the nucleus accumbens enhance the reward value of food consumption and do not induce feeding or REM sleep. Congratulations to first author Katherine Furman (graduate student in the Burgess lab) and to Limei (in the Mattis lab) for her contributions to this publication. This should be the first of many collaborations between our labs!
Dec 19, 2024 - The lab is granted a competitive renewal of the Research Scouts award
We are honored to have been selected for a competitive renewal of the Research Scouts Award from the University of Michigan. The Research Scouts program is an investment in the "Bold Science" objective of Michigan Medicine's research strategic plan, with the goal of catalyzing new and exciting lines of investigation. Scouts Awards are intended to fund early stage ideas that challenge common dogma and have the potential to be paradigm shifting. Thank you to Dr. Bing Ye, the Research Scout who initially selected our lab in 2023, and to the Bold Sciences Team for believing in us and providing this additional investment in our research program!
We are honored to have been selected for a competitive renewal of the Research Scouts Award from the University of Michigan. The Research Scouts program is an investment in the "Bold Science" objective of Michigan Medicine's research strategic plan, with the goal of catalyzing new and exciting lines of investigation. Scouts Awards are intended to fund early stage ideas that challenge common dogma and have the potential to be paradigm shifting. Thank you to Dr. Bing Ye, the Research Scout who initially selected our lab in 2023, and to the Bold Sciences Team for believing in us and providing this additional investment in our research program!
Dec 12, 2024 - Joanna gives a talk at UC Irvine
Joanna was privileged to be invited to give a seminar at the University of California, Irvine, Epilepsy Research Center. It was a great experience to visit with faculty and students in the vibrant EpiCenter research community.
Joanna was privileged to be invited to give a seminar at the University of California, Irvine, Epilepsy Research Center. It was a great experience to visit with faculty and students in the vibrant EpiCenter research community.
Dec 10, 2024 - Anam and Chandni present their work at AES
Anam, Chandni, and Joanna attended the 2024 American Epilepsy Society conference in Los Angeles. Chandni presented her work recording from SNr and PPN neurons in Scn1a+/- mice during seizures. Anam presented her work (a project led by Meiling) recording from noradrenergic neurons in the LC, and measuring norepinephrine release in the hippocampus, during seizures. Both posters were well attended and received very positive and helpful feedback. It was also a worthwhile experience in which we made and strengthened connections with colleagues throughout the research and clinical epilepsy communities.
Anam, Chandni, and Joanna attended the 2024 American Epilepsy Society conference in Los Angeles. Chandni presented her work recording from SNr and PPN neurons in Scn1a+/- mice during seizures. Anam presented her work (a project led by Meiling) recording from noradrenergic neurons in the LC, and measuring norepinephrine release in the hippocampus, during seizures. Both posters were well attended and received very positive and helpful feedback. It was also a worthwhile experience in which we made and strengthened connections with colleagues throughout the research and clinical epilepsy communities.
Nov 02, 2024 - Joanna presents at the Epilepsy Foundation of Michigan’s Wellness & Epilepsy Conference
Joanna was honored to be an invited speaker at the Epilepsy Foundation of Michigan's 2024 Wellness & Epilepsy Conference. Joanna and Dr. Julie Ziobro (pediatric epileptologist) co-presented a talk entitled "Decoding the Genetic Puzzle and its Role in Epilepsy Care". It was a great experience to interact with and support this wonderful foundation as well as the many patients with epilepsy and their family members in attendance.
Joanna was honored to be an invited speaker at the Epilepsy Foundation of Michigan's 2024 Wellness & Epilepsy Conference. Joanna and Dr. Julie Ziobro (pediatric epileptologist) co-presented a talk entitled "Decoding the Genetic Puzzle and its Role in Epilepsy Care". It was a great experience to interact with and support this wonderful foundation as well as the many patients with epilepsy and their family members in attendance.
Nov 01, 2024 - New pre-print on bioRxiv!
We are very excited to share Limei's paper, now available on bioRxiv! Limei performed a detailed characterization of medial septum cholinergic and parvalbumin (PV)-expressing inhibitory interneurons in wild-type versus Dravet Syndrome model mice, and identified significant differences in the PV cells. Congratulations and thank you to Limei and to co-authors Yiannos, Joe, and Juan for their work on this project.
We are very excited to share Limei's paper, now available on bioRxiv! Limei performed a detailed characterization of medial septum cholinergic and parvalbumin (PV)-expressing inhibitory interneurons in wild-type versus Dravet Syndrome model mice, and identified significant differences in the PV cells. Congratulations and thank you to Limei and to co-authors Yiannos, Joe, and Juan for their work on this project.
Oct 12, 2024 - Pumpkin carving party!
Our fall lab social event was a pumpkin carving party, which was a fun chance for everyone to show off their impressive artistic talents. (Zoom in to see Izzy's neuron!)
Our fall lab social event was a pumpkin carving party, which was a fun chance for everyone to show off their impressive artistic talents. (Zoom in to see Izzy's neuron!)
Oct 06, 2024 - Nagham and Krystal present at SfN
Our lab had two posters at the Society for Neuroscience conference this year. Nagham and Krystal both did a fantastic job presenting their work: Krystal shared her findings identifying seizure-associated changes in the PPN, and Nagham presented her data quantifying Sudden Unexpected Death in Epilepsy (SUDEP) rates across different experimental conditions in the Scn1a+/- mouse model. Congratulations!
Our lab had two posters at the Society for Neuroscience conference this year. Nagham and Krystal both did a fantastic job presenting their work: Krystal shared her findings identifying seizure-associated changes in the PPN, and Nagham presented her data quantifying Sudden Unexpected Death in Epilepsy (SUDEP) rates across different experimental conditions in the Scn1a+/- mouse model. Congratulations!
Oct 04, 2024 - Anam receives Biology Travel Award
Anam, an undergraduate student in the lab, received a Biology Travel Award to support her upcoming attendance at the American Epilepsy Society conference, where she will present her research. Congratulations, Anam!
Anam, an undergraduate student in the lab, received a Biology Travel Award to support her upcoming attendance at the American Epilepsy Society conference, where she will present her research. Congratulations, Anam!
Aug 26, 2024 - New year & new lab members!
We're excited to get started with the 2024-2025 academic year! It's great to have all of our undergraduate students back on campus. This year we have four seniors in the lab (Nagham, Rida, Juan, and Izzy), each of whom will be completing an honor's thesis. We are also happy to welcome two new lab members, Maya (sophomore) and Megan (freshman): they both connected with the lab in the spring / summer and are officially getting started this fall. We're looking forward to a wonderful year!
We're excited to get started with the 2024-2025 academic year! It's great to have all of our undergraduate students back on campus. This year we have four seniors in the lab (Nagham, Rida, Juan, and Izzy), each of whom will be completing an honor's thesis. We are also happy to welcome two new lab members, Maya (sophomore) and Megan (freshman): they both connected with the lab in the spring / summer and are officially getting started this fall. We're looking forward to a wonderful year!
Aug 19, 2024 - Joanna presents at the Epilepsy GRC
Joanna presents the lab's work at the Epilepsy Gordon Research Conference, held in New Hampshire.
Aug 19, 2024 - Publication with the Meisler lab in Annals of Neurology
Our second collaborative paper with with Miriam Meisler's lab, Allele-Specific Editing of a Dominant SCN8A Epilepsy Variant Protects Against Seizures and Lethality in a Murine Model, is published in Annals of Neurology. Congratulations to the first author, Wenxi Yu (Research Investigator in the Meisler lab), and Limei and Yiannos (Mattis lab members who contributed to this publication).
Our second collaborative paper with with Miriam Meisler's lab, Allele-Specific Editing of a Dominant SCN8A Epilepsy Variant Protects Against Seizures and Lethality in a Murine Model, is published in Annals of Neurology. Congratulations to the first author, Wenxi Yu (Research Investigator in the Meisler lab), and Limei and Yiannos (Mattis lab members who contributed to this publication).
Aug 16, 2024 - Nagham receives a U@MNI research fellowship
Nagham was awarded a competitive U@MNI undergraduate research fellowship to support her work in the lab. Way to go, Nagham!
Nagham was awarded a competitive U@MNI undergraduate research fellowship to support her work in the lab. Way to go, Nagham!
Aug 01, 2024 - Izzy and Rida present at the Magnificent Michigan fellowship poster session
Izzy and Rida, both supported by the Magnificent Michigan undergraduate summer fellowship, presented their work at a poster session. Our lab benefits greatly from the enthusiasm and hard work of our undergraduate students. Well done, both of you!
Izzy and Rida, both supported by the Magnificent Michigan undergraduate summer fellowship, presented their work at a poster session. Our lab benefits greatly from the enthusiasm and hard work of our undergraduate students. Well done, both of you!
Jul 20, 2024 - lab lake day!
Hudson generously hosted the lab at his family home and we had an amazing day with barbeque, swimming, and boating. It was pure Michigan!
Hudson generously hosted the lab at his family home and we had an amazing day with barbeque, swimming, and boating. It was pure Michigan!
Jul 12, 2024 - Research Highlight publication in eNeuro
Chandni's "Research Highlight", Pan-inhibitory hippocampal neuron ablation reveals insights into the role of interneurons in epileptogeness, was published in eNeuro! Chandni's paper highlights a recent publication from the Danzer laboratory, in which widespread bilateral hippocampal interneuron ablation was found to cause transient seizure clusters and epileptiform activity.
Chandni's "Research Highlight", Pan-inhibitory hippocampal neuron ablation reveals insights into the role of interneurons in epileptogeness, was published in eNeuro! Chandni's paper highlights a recent publication from the Danzer laboratory, in which widespread bilateral hippocampal interneuron ablation was found to cause transient seizure clusters and epileptiform activity.
Jul 03, 2024 - Publication with the Meisler lab in Neurobiology of Disease
We are excited to see our first collaboration with Miriam Meisler's lab come to fruition with a publication in Neurobi0logy of Disease: Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy. Congratulations to all the authors, including the first author, Wenxi Yu (Research Investigator in the Meisler lab), and Limei and Yiannos (Mattis lab members who contributed to this publication). Stay tuned to see what else our labs have been collaborating on!
We are excited to see our first collaboration with Miriam Meisler's lab come to fruition with a publication in Neurobi0logy of Disease: Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy. Congratulations to all the authors, including the first author, Wenxi Yu (Research Investigator in the Meisler lab), and Limei and Yiannos (Mattis lab members who contributed to this publication). Stay tuned to see what else our labs have been collaborating on!
