Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Jun 15, 2023 - The Mattis lab turns 1!
It's hard to believe that our doors opened just one year ago. So proud of the lab and team we've built, and looking forward to the year ahead!

Jun 12, 2023 - Kamie joins the lab for summer 2023
We are very excited to welcome Kamie, a rising sophomore at Johns Hopkins, to the lab for the summer. Kamie is studying biomedical engineering and has previously worked as a research assistant in Dr. Lisa Larkin’s Skeletal Tissue Engineering Laboratory at UMich.

Jun 12, 2023 - Shahriar joins the lab for summer 2023
We are very excited to welcome Shahriar, a rising senior at Kalamazoo College, as an undergraduate student researcher for the summer of 2023. Shahriar is majoring in Computer Science with a Neuroscience concentration and a minor in Psychology. He received an Internship Stipend Award as well as the competitive Hough Foundation Grant from Kalamazoo College in support of his summer research. Congratulations and welcome, Shahriar!

Jun 12, 2023 - Meiling joins the lab
We are thrilled to welcome Meiling to the Mattis lab as our second postdoc! Meiling completed her PhD in the Department of Molecular, Cellular, and Developmental Biology, along with a dual master's degree in the Department of Computational Medicine and Bioinformatics, both at the University of Michigan. Working in Sam Kwon's lab, she uncovered neuronal mechanisms of impaired perceptual learning associated with neurodevelopmental disorders using a mouse model of Synaptic Ras-GTPase-activating protein (SynGAP), behavioral testing, and in vivo two-photon calcium imaging.

Jun 05, 2023 - Krystal is selected for the PSTP T32!
We are so excited to share the news that Krystal has been selected to to be appointed as a trainee on the highly competitive Pharmacological Sciences Training Program (PSTP) T32 training grant. This training program is a collaboration between the Medical School and the College of Pharmacy, designed to provide translational education, research training, and career development for trainees, to equip them as leaders in the field of experimental therapeutics. Congratulations, Krystal!!!

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