Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Nov 30, 2023 - Meiling is awarded a DSF postdoctoral fellowship!
Meiling was selected for a postdoctoral fellowship award from the Dravet Syndrome Foundation! The DSF supports and funds research on Dravet syndrome with the aims of finding new treatments and improving the quality of life for people living with Dravet Syndrome. Thank you, DSF, and congratulations, Meiling!

Nov 28, 2023 - Nagham presents at an undergraduate poster session
Nagham gives a poster presentation of her project to cap off her independent study research course. Congratulations, Nagham!

Oct 20, 2023 - Krystal gives a Department of Pharmacology seminar
Krystal presents her work to the Department of Pharmacology. The talk was very well attended and the audience asked many great questions. Well done, Krystal!

Oct 19, 2023 - Joanna gives an NETP seminar
Joanna gives a seminar for the Neural Engineering Training Program. Thanks for all the great questions!

Oct 16, 2023 - Joanna presents at PCEM
Joanna gives an invited talk at the Park City Epilepsy Meeting. This is a wonderful meeting focused on neuroscience as applied to therapy development for the treatment of epilepsy. Thank you to the meeting co-chairs, Karen Wilcox and Scott Baraban, for the invitation!

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