Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Oct 06, 2024 - Nagham and Krystal present at SfN
Our lab had two posters at the Society for Neuroscience conference this year. Nagham and Krystal both did a fantastic job presenting their work. Congratulations!

Oct 04, 2024 - Anam receives Biology Travel Award
Anam, an undergraduate student in the lab, received a Biology Travel Award to support her upcoming attendance at the American Epilepsy Society conference, where she will present her research. Congratulations, Anam!

Aug 26, 2024 - New year & new lab members!
We're excited to get started with the 2024-2025 academic year! It's great to have all of our undergraduate students back on campus. This year we have four seniors in the lab (Nagham, Rida, Juan, and Izzy), each of whom will be completing an honor's thesis. We are also happy to welcome two new lab members, Maya (sophomore) and Megan (freshman): they both connected with the lab in the spring / summer and are officially getting started this fall. We're looking forward to a wonderful year!

Aug 19, 2024 - Joanna presents at the Epilepsy GRC

Joanna presents the lab's work at the Epilepsy Gordon Research Conference, held in New Hampshire.

Aug 19, 2024 - Publication in Annals of Neurology
Our second collaborative paper with with Miriam Meisler's lab, Allele-Specific Editing of a Dominant SCN8A Epilepsy Variant Protects Against Seizures and Lethality in a Murine Model, is published in Annals of Neurology. Congratulations to the first author, Wenxi Yu (Research Investigator in the Meisler lab), and Limei and Yiannos (Mattis lab members who contributed to this publication).

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