Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Sep 13, 2023 - Kat joins the lab
We are so glad to welcome Katherine (Kat) Reaume to the lab as a research assistant! Kat is an MSU graduate with a B.S. in neuroscience and a minor in philosophy. She is working as an EEG technician at Beaumont Hospital while also completing a post-bac at MSU, all towards her future goal to become a doctor. Welcome, Kat!

Aug 28, 2023 - Izzy joins the lab
We are happy to welcome Isabella (Izzy) Plati to the Mattis lab! She joins our lab as a fourth-year neuroscience student at the University of Michigan. Her prior research experience includes investigation of phenotype inheritance in the nematode C. elegans. She is highly active in the community, including working with an organization called Medicine4Youth and leading a team of high school students to complete a research project. She aspires to become a physician-scientist specializing in pediatric epilepsy. Welcome, Izzy!

Aug 22, 2023 - Saying farewell to our summer students
Lab dinner at the Ann Arbor "1923 Taco Bus" to celebrate the end of the summer, and to say goodbye to our three wonderful summer students, Kami, Shahriar, and Jade.

Aug 16, 2023 - Rida receives a U@MNI research fellowship
Rida Qureshi was awarded a competitive U@MNI undergraduate research fellowship to support her work in the lab. Congratulations, Rida!

Aug 04, 2023 - Julia heads to grad school
Julia Kravchenko, one of the lab's founding members, has "graduated" from being a technician in the lab and is starting a PhD in the Neuroscience Graduate Program at the University of Michigan! She'll be greatly missed, but we're excited for her (and glad she'll still be nearby). Best wishes, Julia!

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