Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have already built a vibrant and productive lab community!

Mattis lab, June 2023

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Jun 14, 2025 - 2025 Metro Detroit Stroll for Epilepsy
Members of our lab and other UofM faculty, staff, and students joined the 2025 Metro Detroit Stroll for Epilepsy, organized by the Michigan Epilepsy Foundation. It was an inspirational event, with many epilepsy patients and their families in attendance, and a beautiful day to enjoy the Detroit Zoo!

Jun 06, 2025 - Krystal gives a talk at the 2025 Pharmacology in Color Symposium
Congratulations to Krystal on her excellent invited talk at this year's Pharmacology in Color Symposium. Krystal shared her exciting preliminary data regarding mechanisms of Sudden Unexpected Death in Epilepsy (SUDEP), the most dreaded complication of epilepsy. Well done, Krystal!

May 16, 2025 - Nagham’s poster is selected for a prize at the U-M Neuroscience conference
Nagham's poster was selected (based upon votes by conference attendees) for a prize at the University of Michigan Neuroscience conference. This was notably a general prize, not limited to undergraduate students. Congratulations, Nagham!

May 04, 2025 - Congratulations to graduates from our lab!
Congrats to Joe (MCDB) for completing his master's, and to Izzy and Rida (Neuroscience) and Nagham (Psychology) for completing their undergraduate degrees. Major milestones all around!

Apr 28, 2025 - Congratulations to our seniors!
A lovely evening celebrating our lab's seniors - Juan, Nagham, Izzy, and Rida - and their mentors. Thank you, all, for your contributions to the lab. And congratulations!

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