Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Mattis lab, Nov 2022

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Mar 01, 2023 - Krystal officially joins the lab!
We are thrilled to welcome Krystal M. Santiago-Colón as the lab's first official graduate student! Krystal graduated from the University of Puerto Rico, Cayey Campus with a B.S. in Biology in 2022. She is a student in the Program in Biomedical Sciences (PIBS) and the Department of Pharmacology. Krystal will be jointly mentored by Dr. Lori Isom, Chair of the Department of Pharmacology.

Feb 28, 2023 - Setting up an automated fluorescent microscope + stereology system!
Today our new automated Nikon fluorescent microscope was installed! We'll be using this alongside a MBF Biosciences software for stereology. So excited to start taking pictures on this microscope!

Feb 15, 2023 - Setting up the slice rig!
The Mattis Lab now has a beautiful ephys rig for slice physiology, with integrated multi-color LED illumination for optogenetics. Thank you, Scientifica, Olympus, and Molecular Devices!

Feb 02, 2023 - First whole cell patch clamp recording!
Slice electrophysiology is happening in the Mattis lab! And in just a few weeks we'll be able to move over onto our very own rig.

Feb 01, 2023 - Limei joins the lab
We are very excited to welcome Limei to the Mattis lab as our first postdoc! Limei previously completed a postdoc in Dr. Bing Ye's lab at the University of Michigan, where she investigated the mechanism of the high temporal resolution of sensory neurons in drosophila larvae.

1 2 3 5 Next › Last »