Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Mattis lab, Nov 2022

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Feb 02, 2023 - First whole cell patch clamp recording!
Slice electrophysiology is happening in the Mattis lab! And in just a few weeks we'll be able to move over onto our very own rig.

Jan 30, 2023 - First EEG recording!
We hooked up our first mice today and were so excited to see that we are able to record lovely EEG signal!

Jan 30, 2023 - Chandni rotates in the lab
We are very happy to welcome graduate student Chandni Rana (NGP) to the lab for a rotation.

Jan 04, 2023 - First graduate students rotating in the lab
We are very happy to welcome graduate students Krystal Santiago-Colón (pharmacology) and Jacob Reeves (NGP) to the lab this winter.

Dec 24, 2022 - First paper accepted: “Optogenetic and chemogenetic manipulation of seizure threshold in mice”
We were thrilled to learn that the Mattis lab's first paper has been accepted for publication in STAR Protocols! In this paper, we detail a protocol for the use of optogenetics or chemogenetics to assess the neuronal circuits contributing to seizure initiation, with a focus on hyperthermia-induced seizures. Congratulations to first author Julia Kravchenko!

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