Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a vibrant and productive lab community!

BSRB

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

2024-04-29 17:22:10 - Izzy and Rida both receive summer research awards!
Izzy and Rida were both selected for Neuroscience Summer Research Fellowships! Izzy's fellowship is through the Undergraduate Program in Neuroscience (UPiN) and Rida's is through the Program in Biology (PiB). These awards will support their full time research in the lab this summer. They will also both be Magnificent Michigan Summer Undergraduate Research Fellows, supported by the Michigan Neuroscience Institute MNI). Congratulations to both of them!

2024-04-24 15:28:11 - Rida presents at UROP’s spring research symposium
Rida presented a poster at the Undergraduate Research Opportunity Program (UROP) Spring Research Symposium, highlighting her work targeting the nigro-tegmental pathway with stereotactic viral injections in transgenic mice. Great job, Rida!

2024-04-21 05:46:33 - Cookie decorating party
The lab's spring social event was a cookie decorating party at Joanna's house. It was a great time!

2024-04-12 22:36:37 - Krystal passed her prelims!
The preliminary exam is a major milestone for PhD students in the Department of Pharmacology at UofM. This entails developing a topic (outside of the lab's focus), writing an abstract, specific aims, and research strategy, and finally passing an oral exam. Congratulations, Krystal!

2024-04-10 22:40:04 - Joanna presents a BERG seminar

Joanna presents the lab's work to the Basic Epilepsy Research Group at the University of Michigan. This was Joanna's first full hour-long talk exclusively consisting of new data from the Mattis lab, which is an exciting milestone - and reflective of the fact that we've now collected lots of data!

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