Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have already built a vibrant and productive lab community!

Mattis lab, June 2023

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Feb 01, 2023 - Limei joins the lab
We are very excited to welcome Limei to the Mattis lab as our first postdoc! Limei previously completed a postdoc in Dr. Bing Ye's lab at the University of Michigan, where she investigated the mechanism of the high temporal resolution of sensory neurons in drosophila larvae.

Jan 30, 2023 - First EEG recording!
We hooked up our first mice today and were so excited to see that we are able to record lovely EEG signal!

Jan 30, 2023 - Chandni rotates in the lab
We are very happy to welcome graduate student Chandni Rana (NGP) to the lab for a rotation.

Jan 04, 2023 - First graduate students rotating in the lab
We are very happy to welcome graduate students Krystal Santiago-Colón (pharmacology) and Jacob Reeves (NGP) to the lab this winter.

Dec 24, 2022 - First paper accepted: “Optogenetic and chemogenetic manipulation of seizure threshold in mice”
We were thrilled to learn that the Mattis lab's first paper has been accepted for publication in STAR Protocols! In this paper, we detail a protocol for the use of optogenetics or chemogenetics to assess the neuronal circuits contributing to seizure initiation, with a focus on hyperthermia-induced seizures. Congratulations to first author Julia Kravchenko!

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