Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a vibrant and productive lab community!

BSRB

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

May 03, 2024 - Krystal is selected as a Neuroscience Scholars Program fellow!
Congratulations to Krystal for being selected as a Neuroscience Scholars Program (NSP) Fellow! This program, through the Society for Neuroscience, provides trainees with career development and network opportunities.

May 02, 2024 - Joanna presents at the University of New Mexico
Joanna presents the lab's work to the Department of Neuroscience at the University of New Mexico. Thank you for the invitation!

Apr 29, 2024 - Izzy and Rida both receive summer research awards!
Izzy and Rida were both selected for Neuroscience Summer Research Fellowships! Izzy's fellowship is through the Undergraduate Program in Neuroscience (UPiN) and Rida's is through the Program in Biology (PiB). These awards will support their full time research in the lab this summer. They will also both be Magnificent Michigan Summer Undergraduate Research Fellows, supported by the Michigan Neuroscience Institute MNI). Congratulations to both of them!

Apr 24, 2024 - Rida presents at UROP’s spring research symposium
Rida presented a poster at the Undergraduate Research Opportunity Program (UROP) Spring Research Symposium, highlighting her work targeting the nigro-tegmental pathway with stereotactic viral injections in transgenic mice. Great job, Rida!

Apr 21, 2024 - Cookie decorating party
The lab's spring social event was a cookie decorating party at Joanna's house. It was a great time!

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