Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Aug 22, 2023 - Saying farewell to our summer students
Lab dinner at the Ann Arbor "1923 Taco Bus" to celebrate the end of the summer, and to say goodbye to our three wonderful summer students, Kami, Shahriar, and Jade.

Aug 16, 2023 - Rida receives a U@MNI research fellowship
Rida Qureshi was awarded a competitive U@MNI undergraduate research fellowship to support her work in the lab. Congratulations, Rida!

Aug 04, 2023 - Julia heads to grad school
Julia Kravchenko, one of the lab's founding members, has "graduated" from being a technician in the lab and is starting a PhD in the Neuroscience Graduate Program at the University of Michigan! She'll be greatly missed, but we're excited for her (and glad she'll still be nearby). Best wishes, Julia!

Jun 15, 2023 - The Mattis lab turns 1!
It's hard to believe that our doors opened just one year ago. So proud of the lab and team we've built, and looking forward to the year ahead!

Jun 12, 2023 - Kamie joins the lab for summer 2023
We are very excited to welcome Kamie, a rising sophomore at Johns Hopkins, to the lab for the summer. Kamie is studying biomedical engineering and has previously worked as a research assistant in Dr. Lisa Larkin’s Skeletal Tissue Engineering Laboratory at UMich.

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