Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Mattis lab, Nov 2022

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Dec 22, 2022 - Yiannos joins the lab
We are very happy to welcome Yiannos Demetriou as a new undergraduate student in the Mattis lab, starting January 2023! Yiannos is a triple major at the University of Michigan. He has multiple research experiences, ranging from designing and developing a virtual reality application, to writing and testing commands for a spider robot, to using Machine Learning to identify tinnitus in guinea pigs.

Dec 14, 2022 - Limei joins the lab
We are very excited that Limei will be joining the Mattis lab as our first postdoc, starting February 2023! Limei is currently a postdoc in Dr. Bing Ye's lab at the University of Michigan, where she is investigating the mechanism of the high temporal resolution of sensory neurons in drosophila larvae.

Dec 13, 2022 - Setting up the 2-photon!
The Mattis Lab now has a 2-photon microscope! Thank you, Bruker! We look forward to slice and in vivo imaging, coupled with optogenetic stimulation.

Dec 01, 2022 - Joanna presents at the DSF Research Roundtable
Joanna gives an invited talk at the Dravet Syndrome Foundation Research Roundtable, held just prior to the American Epilepsy Society Annual Meeting in Nashville, Tennessee.

Nov 09, 2022 - Juan joins the lab
We are happy to welcome Juan Disla as a new undergraduate student in the Mattis lab! He will be officially joining winter 2023 but has been getting a head start this fall. Welcome, Juan!

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