Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have already built a vibrant and productive lab community!

Mattis lab, June 2023

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Apr 28, 2025 - Congratulations to our seniors!
A lovely evening celebrating our lab's seniors - Juan, Nagham, Izzy, and Rida - and their mentors. Thank you, all, for your contributions to the lab. And congratulations!

Apr 28, 2025 - Alex & Ruitao awarded summer research fellowships
Alex Hollier and Ruitao Shen were both awarded undergraduate Neuroscience Summer Research Fellowships through the UM Program in Biology. This will support their full time summer research in the lab. Congrats, Alex & Ruitao!

Apr 07, 2025 - Alex awarded a Magnificent Michigan Summer Undergraduate research fellowship
Alex Hollier was awarded a Magnificent Michigan Summer Undergraduate research fellowship to support his full time work in the lab this summer. Congratulations, Alex!

Apr 07, 2025 - Nagham selected as Psychology department nominee for LSA honors
Nagham was selected as the Psychology department nominee for both the Elizabeth Hume O'Donnell Honors Graduation Prize and the Marshall Nirenberg Life Sciences Award (Goldstein Prize) LSA Honors awards. This nomination was based on the quality of her senior honor's thesis and her overall research performance throughout her time as an undergraduate student in the lab. Congratulations, Nagham, on this well-deserved honor!

Apr 01, 2025 - Welcoming a “mini team” of CS undergrads to the Mattis lab!
We are very excited to welcome a "mini team" of UMich CS students to the lab to contribute to our data analysis efforts! Sreyashi Mondal and Alexander Sajdak are sophomores studying CS. Saif Siddiqui is a junior studying CS on the pre-medical track. We think there's a lot to gain by bringing computer science students into a neuroscience lab, and we are looking forward to working together!

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