Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Mattis lab, June 2023

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Oct 12, 2023 - Joanna presents at the Kresge Hearing Research Institute HBCS Seminar
Joanna gives an invited talk at the Hearing, Balance, and Chemical Senses (HBCS) Seminar Series. Thanks for the great questions and feedback!

Oct 12, 2023 - Anam joins the lab
We are pleased to welcome Anam Noor to the Mattis lab! She is freshman neuroscience student at the University of Michigan. She has a passion for neuroscience and aspires to become a neurologist. Welcome to the lab, Anam!

Oct 09, 2023 - First seizure recording using Open Ephys!
Open Ephys is working, as evidenced by this beautiful seizure recording! This platform will enable our lab to set up a closed-loop system in which real-time, automated seizure detection triggers optogenetic stimulation.

Sep 13, 2023 - Kat joins the lab
We are so glad to welcome Katherine (Kat) Reaume to the lab as a research assistant! Kat is an MSU graduate with a B.S. in neuroscience and a minor in philosophy. She is working as an EEG technician at Beaumont Hospital while also completing a post-bac at MSU, all towards her future goal to become a doctor. Welcome, Kat!

Aug 28, 2023 - Izzy joins the lab
We are happy to welcome Isabella (Izzy) Plati to the Mattis lab! She joins our lab as a fourth-year neuroscience student at the University of Michigan. Her prior research experience includes investigation of phenotype inheritance in the nematode C. elegans. She is highly active in the community, including working with an organization called Medicine4Youth and leading a team of high school students to complete a research project. She aspires to become a physician-scientist specializing in pediatric epilepsy. Welcome, Izzy!

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