Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we are looking forward to building a diverse and vibrant lab community!

Joanna Mattis
Principal Investigator

Research

Our research combines electrophysiology, optogenetics, chemogenetics, and imaging techniques in preclinical experimental models of epilepsy. We use this approach to study

Circuit dysfunction in the temporal lobe, focusing on the dynamic changes around seizure onset, and
Subcortical neuromodulatory networks in seizures and epilepsy.

Corticohippocampal circuit dysfunction in epilepsy

Neuromodulatory networks in epilepsy

Lab News

Jun 01, 2022 - Joe joins the lab
Joseph Barden joins the lab as a Research Laboratory Specialist Associate. Joe is an experienced technician and laboratory manager, as well as an avid pianist. Welcome, Joe!

Mar 14, 2022 - Joanna publishes in eLife
Joanna’s post-doc paper (with mentor Dr. Ethan Goldberg at CHOP) is published! Read about “Corticohippocampal circuit dysfunction in a mouse model of Dravet Syndrome”: https://elifesciences.org/articles/69293

Jan 27, 2022 - Coming to Michigan!
Joanna formally signs on to join the Department of Neurology at the University of Michigan.

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