Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a vibrant and productive lab community!

BSRB

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

May 15, 2023 - Chandni presents at the NETP Symptosium
Chandni presented her project at the annual Neural Engineering Training Program Symposium. This was our lab's first presentation of new data (collected within the Mattis lab), which is a major milestone!

Apr 26, 2023 - Joe is admitted to the MCDB Masters of Science program at UofM!
Very proud to announce that Joe will be pursuing an MS in the Department of Molecular, Cellular, and Developmental Biology (MCDB) beginning fall term, 2023! Fortunately for us, he'll still be able to continuing his position in the lab at the same time. Way to go, Joe!

Apr 25, 2023 - Joanna presents at the American Academy of Neurology conference
Joanna gives an invited talk at the AAN Research Career Symposium in Boston.

Apr 14, 2023 - First fiber photometry experiment is underway!
So thrilled to be collecting fiber photometry and ECoG data during seizures! Great job Chandni, and thank you so much to Burgess lab collaborating with us on this!

Apr 03, 2023 - Chandni is selected as a student rep for the NGP DEI committee
Congratulations, Chandni!

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