Current

NINDS logo

Title: Cortico-hippocampal circuit dysfunction in an Scn1a mouse model of epilepsy
Major Goals: The major goals of this project are to 1) identify the cause of hyperexcitability in the cortico-hippocampal circuit in young adult Scn1a mice and 2) establish the relevance of this circuit hyperexcitability to seizure initiation in vivo.
Project Number: K08NS121464
Name of PD/PI: Mattis, J.H.
Source of Support: NIH NINDS (https://www.ninds.nih.gov/)
Start and End Date: 07/2021 – 06/2026

Pending

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Title: Harnessing neuromodulation to target peri-ictal dysfunction in epilepsy
Major Goals: The major goals of this project are to 1) determine the activity of the neuromodulatory noradrenergic neurons at seizure onset and 2) test whether activating these neurons is therapeutic in epilepsy.
Name of PD/PI: Mattis, J.H.
Source of Support: CURE Epilepsy (https://www.cureepilepsy.org/)
Project/Proposal Start and End Date: 10/2022 – 09/2023