Mattis Lab – Dissecting the circuit mechanisms of epilepsy

Our long-term goal is to develop new epilepsy treatments that are rationally designed to target precise circuit elements. We investigate how neuronal circuits are dysfunctional in epilepsy, and how these circuits can be modified to improve seizures.

The Mattis Lab is located in the Ann Arbor campus of the University of Michigan. We are affiliated with the Department of Neurology and with the Michigan Neuroscience Institute (MNI). The lab was founded June 2022, and we have built a vibrant and productive lab community!

BSRB

Research

Our research combines slice and in vivo electrophysiology, optogenetics, chemogenetics, and imaging techniques (2-photon and fiber photometry) in preclinical experimental models of epilepsy. We use this approach to study

The role of subcortical neuromodulatory networks in seizures
How subcortical neuromodulatory networks are chronically impacted in epilepsy

The role of subcortical neuromodulatory networks in seizures

The impact of chronic epilepsy on neuromodulatory networks

Lab News

Dec 01, 2025 - Juan completes his honors thesis
Congratulations to Juan Disla for the completion of his honors thesis! It has been a pleasure having Juan in the lab and we wish him well on his future endeavors.

Nov 20, 2025 - Udai joins the lab
We are happy to welcome our latest lab member, Udaiveer Gill, to the lab as an undergraduate researcher. Udai is a freshman neuroscience major at UofM.

Nov 17, 2025 - Society for Neuroscience 2025
Our lab presented 4 posters at SfN this year! All projects are approaching submission for publication and it was a great opportunity to get feedback. Congratulations to Ruitao, Chandni, Krystal, and Meiling for their great work!

Nov 13, 2025 - Distinct Circuit Mechanisms in Epilepsies
Joanna gave a talk at "Distinct Circuit Mechanisms in Epilepsies" - a.k.a. "Huguenardapalooza" - an SfN pre-meeting organized in honor of Dr. John Huguenard, one of Joanna's PhD mentors at Stanford. Thank you to the organizers for the invitation, and congratulations, Dr. Huguenard, on your many accomplishments as a scientist and as a mentor!

Oct 24, 2025 - Halloween “Horror Night”
The lab celebrated an early Halloween with dinner out followed by a haunted house expedition. Spooky fun was had by all!

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